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1

The effectiveness of risk communication regarding drug safety information: a nationwide survey by the Japanese public health insurance claims data

Hagiwara, Hiromi, Nakano, Shun, Ogawa, Yoshihiro, Tohkin, Masahiro

Journal:

Journal of Clinical Pharmacy and Therapeutics

Year:

2015

Language:

english

File:

PDF, 566 KB

english, 2015

2

Possible Causes of Failing to Meet Primary Endpoints

Ikeda, Mitsugu, Ochibe, Tatsuya, Tohkin, Masahiro

Journal:

Therapeutic Innovation & Regulatory Science

Year:

2018

Language:

english

File:

PDF, 321 KB

english, 2018

3

Recombinant human glucagon: Large-scale purification and biochemical characterization

Kazumasa Yoshikawa, Hiroshige Tsuzuki, Masafumi Fujimoto, Masahiro Tohkin, Takashi Matsubara, Hiroshi Yonezawa, Hiroyuki Okamoto, Hiroshi Teraoka, Nobuo Yoshida

Journal:

The Protein Journal

Year:

1992

Language:

english

File:

PDF, 1016 KB

english, 1992

4

Comparative study of inhibitory effects by murine interferon γ and a new bisphosphonate (alendronate) in hypercalcemic, nude mice bearing human tumor (LJC-1-JCK)

Masahiro Tohkin, Shinji Kakudo, Hisashi Kasai, Hitoshi Arita

Journal:

Cancer Immunology, Immunotherapy

Year:

1994

Language:

english

File:

PDF, 669 KB

english, 1994

5

5′ Diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site

Kouichi Kurose, Satoru Koyano, Shinobu Ikeda, Masahiro Tohkin, Ryuichi Hasegawa, Jun-Ichi Sawada

Journal:

Molecular and Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 904 KB

english, 2005

6

Identification of regulatory sites in the humanPXR(NR1I2) promoter region

Kouichi Kurose, Shinobu Ikeda, Satoru Koyano, Masahiro Tohkin, Ryuichi Hasegawa, Jun-ichi Sawada

Journal:

Molecular and Cellular Biochemistry

Year:

2006

Language:

english

File:

PDF, 1.15 MB

english, 2006

7

HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients

Nahoko Kaniwa, Yoshiro Saito, Michiko Aihara, Kayoko Matsunaga, Masahiro Tohkin, Kouichi Kurose, Hirokazu Furuya, Yukitoshi Takahashi, Masaaki Muramatsu, Shigeru Kinoshita, Masamichi Abe, Hiroko Ikeda

Journal:

Year:

2010

Language:

english

File:

PDF, 70 KB

english, 2010

8

Transcription factor NF2d9 (LBP-1a) interacts with the positive regulatory element for the xenobiotic responsive element

Kouichi Kurose, Masahiro Tohkin, Ryuichi Hasegawa

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

2005

Language:

english

File:

PDF, 193 KB

english, 2005

9

Identification of the functional vitamin D response elements in the human MDR1 gene

Mayumi Saeki, Kouichi Kurose, Masahiro Tohkin, Ryuichi Hasegawa

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.44 MB

english, 2008

10

Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver

Shoko Sato, Hitoshi Shirakawa, Shuhei Tomita, Yusuke Ohsaki, Keiichi Haketa, Osamu Tooi, Noriaki Santo, Masahiro Tohkin, Yuji Furukawa, Frank J. Gonzalez, Michio Komai

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 378 KB

english, 2008

11

cDNA cloning and expression of a novel CYP3A from the Syrian hamster, CYP3A31

Samira Alabouch, Kouichi Kurose, Masahiro Tohkin, Marie-Hélène Bani, Morio Fukuhara, Kiyoshi Nagata, Yasushi Yamazoe

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1998

Language:

english

File:

PDF, 260 KB

english, 1998

12

Molecular cloning, heterologous expression, and characterization of a novel member of CYP2A in the Syrian hamster

Masahiro Tohkin, Kouichi Kurose, Emi Isozaki, Morio Fukuhara

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1999

Language:

english

File:

PDF, 302 KB

english, 1999

13

Possible interaction of α1-adrenergic receptor with pertussis-toxin-sensitive guanine-nucleotide-binding regulatory proteins (G proteins) responsible for phospholipase C activation in rat liver plasma membranes

Masahiro TOHKIN, Tatsurou YAGAMI, Toshiaki KATADA, Takashi MATSUBARA

Journal:

Year:

1990

Language:

english

File:

PDF, 784 KB

english, 1990

14

Interaction of guanine-nucleotide-binding regulatory proteins with chemotactic peptide receptors in differentiated human leukemic HL-60 cells

Masahiro TOHKIN, Naoki MORISHIMA, Taroh IIRI, Katsunobu TAKAHASHI, Michio UI, Toshiaki KATADA

Journal:

Year:

1991

Language:

english

File:

PDF, 864 KB

english, 1991

15

Cloning and Characterization of Syrian Hamster Testosterone 7α-Hydroxylase, CYP2A9

Kouichi Kurose, Masahiro Tohkin, Fusao Ushio, Morio Fukuhara

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 240 KB

english, 1998

16

Evidence for Involvement of cAMP-Dependent Pathway in the Phenobarbital-Induced Expression of a Novel Hamster Cytochrome P450, CYP3A31

Marie-Hélène Bani, Masahiro Tohkin, Fusao Ushio, Morio Fukuhara

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 1.85 MB

english, 1998

17

Cloning and Expression Analysis of a New Member of the Cytochrome P450, CYP2A15 from the Chinese Hamster, Encoding Testosterone 7α-Hydroxylase

Kouichi Kurose, Emi Isozaki, Masahiro Tohkin, Morio Fukuhara

Journal:

Archives of Biochemistry and Biophysics

Year:

1999

Language:

english

File:

PDF, 123 KB

english, 1999

18

Proliferative effect of phospholipase A2 in rat chondrocyte via its specific binding sites

Junji Kishino, Masahiro Tohkin, Hitoshi Arita

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 436 KB

english, 1992

19

GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin

Koh-ichi Nagata, Toshiaki Katada, Masahiro Tohkin, Hiroshi Itoh, Yoshito Kaziro, Michio Ui, Yoshinori Nozawa

Journal:

Year:

1988

Language:

english

File:

PDF, 1.11 MB

english, 1988

20

Inhibition by islet-activating protein, pertussis toxin, of retinoic acid-induced differentiation of human leukemic (HL-60) cells

Masahiro Tohkin, Taroh Iiri, Michio Ui, Toshiaki Katada

Journal:

Year:

1989

Language:

english

File:

PDF, 237 KB

english, 1989

21

Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes

Masahiro Tohkin, Tatsurou Yagami, Takashi Matsubara

Journal:

Year:

1990

Language:

english

File:

PDF, 423 KB

english, 1990

22

Thyroid hormone receptor mediates human MDR1 gene expression—Identification of the response region essential for gene expression

Kouichi Kurose, Mayumi Saeki, Masahiro Tohkin, Ryuichi Hasegawa

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

23

Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes

Kazuko Suzuki, Tatsuo Yanagawa, Toshiaki Shibasaki, Nahoko Kaniwa, Ryuichi Hasegawa, Masahiro Tohkin

Journal:

Diabetes Research and Clinical Practice

Year:

2006

Language:

english

File:

PDF, 141 KB

english, 2006

24

Functional analysis of genetic variations in the 5′-flanking region of the human MDR1 gene

Mayumi Saeki, Kouichi Kurose, Ryuichi Hasegawa, Masahiro Tohkin

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 504 KB

english, 2011

25

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Christopher J Sinal, Masahiro Tohkin, Masaaki Miyata, Jerrold M Ward, Gilles Lambert, Frank J Gonzalez

Journal:

Year:

2000

Language:

english

File:

PDF, 545 KB

english, 2000

26

The involvement of the stimulatory G protein in sexual dimorphism of β-adrenergic receptor-mediated functions in rat liver

Tatsurou Yagami, Masahiro Tohkin, Takashi Matsubara

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1994

Language:

english

File:

PDF, 649 KB

english, 1994

27

A detection algorithm for drug-induced liver injury in medical information databases using the Japanese diagnostic scale and its comparison with the Council for International Organizations of Medical Sciences/the Roussel Uclaf Causality Assessment Method

Hanatani, Tadaaki, Sai, Kimie, Tohkin, Masahiro, Segawa, Katsunori, Kimura, Michio, Hori, Katsuhito, Kawakami, Junichi, Saito, Yoshiro

Journal:

Pharmacoepidemiology and Drug Safety

Year:

2014

Language:

english

File:

PDF, 254 KB

english, 2014

28

The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A

Sato, Shoko, Shirakawa, Hitoshi, Tomita, Shuhei, Tohkin, Masahiro, Gonzalez, Frank J., Komai, Michio

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 612 KB

english, 2013

29

Specific HLA types are associated with antiepileptic drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese subjects

Kaniwa, Nahoko, Sugiyama, Emiko, Saito, Yoshiro, Kurose, Kouichi, Maekawa, Keiko, Hasegawa, Ryuichi, Furuya, Hirokazu, Ikeda, Hiroko, Takahashi, Yukitoshi, Muramatsu, Masaaki, Tohkin, Masahiro, Ozeki,

Journal:

Pharmacogenomics

Year:

2013

Language:

english

File:

PDF, 838 KB

english, 2013

30

Antihepatotoxic Principles of Atractylodes Rhizomes

Kiso, Yoshinobu, Tohkin, Masahiro, Hikino, Hiroshi

Journal:

Journal of Natural Products

Year:

1983

Language:

english

File:

PDF, 249 KB

english, 1983

31

Assay Method For Antihepatotoxic Activity Using Galactosamine-Induced Cytotoxicity in Primary-Cultured Hepatocytes

Kiso, Yoshinobu, Tohkin, Masahiro, Hikino, Hiroshi

Journal:

Journal of Natural Products

Year:

1983

Language:

english

File:

PDF, 425 KB

english, 1983

32

HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis

Kaniwa, Nahoko, Saito, Yoshiro, Aihara, Michiko, Matsunaga, Kayoko, Tohkin, Masahiro, Kurose, Kouichi, Sawada, Jun-ichi, Furuya, Hirokazu, Takahashi, Yukitoshi, Muramatsu, Masaaki, Kinoshita, Shigeru,

Journal:

Pharmacogenomics

Year:

2008

Language:

english

File:

PDF, 317 KB

english, 2008

33

Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients

Hanatani, Tadaaki, Sai, Kimie, Tohkin, Masahiro, Segawa, Katsunori, Saito, Yoshiro

Journal:

International Journal of Clinical Pharmacy

Year:

2015

Language:

english

File:

PDF, 793 KB

english, 2015

34

Prediction of Severe Adverse Drug Reactions Using Pharmacogenetic Biomarkers

Tohkin, Masahiro, Ishiguro, Akihiro, Kaniwa, Nahoko, Saito, Yoshiro, Kurose, Kouichi, Hasegawa, Ryuichi

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 265 KB

english, 2010

35

Antihepatotoxic Actions of Allium sativum Bulbs 1

Hikino, Hiroshi, Tohkin, Masahiro, Kiso, Yoshinobu, Namiki, Tsuneo, Nishimura, Shoji, Takeyama, Kimori

Journal:

Year:

1986

Language:

english

File:

PDF, 468 KB

english, 1986

36

Mechanism of Antihepatotoxic Activity of Atractylon, I: Effect on Free Radical Generation and Lipid Peroxidation 1

Kiso, Yoshinobu, Tohkin, Masahiro, Hikino, Hiroshi

Journal:

Year:

1985

Language:

english

File:

PDF, 353 KB

english, 1985

37

Mechanism of Antihepatotoxic Activity of Wuweizisu C and Gomisin A

Kiso, Yoshinobu, Tohkin, Masahiro, Hikino, Hiroshi, Ikeya, Yukinobu, Taguchi, Heihachiro

Journal:

Year:

1985

Language:

english

File:

PDF, 351 KB

english, 1985

38

Mechanism of Antihepatotoxic Activity of Glycyrrhizin, I: Effect on Free Radical Generation and Lipid Peroxidation

Kiso, Yoshinobu, Tohkin, Masahiro, Hikino, Hiroshi, Hattori, Masao, Sakamoto, Tatsuya, Namba, Tsuneo

Journal:

Year:

1984

Language:

english

File:

PDF, 488 KB

english, 1984

39

Development of a Rapid and Inexpensive Assay for Detecting a Surrogate Genetic Polymorphism of HLA-B*58:01: A Partially Predictive but Useful Biomarker for Allopurinol-related Stevens-Johnson Syndrome/toxic Epidermal Necrolysis in Japanese

Maekawa, Keiko, Nishikawa, Jun, Kaniwa, Nahoko, Sugiyama, Emiko, Koizumi, Tomoko, Kurose, Kouichi, Tohkin, Masahiro, Saito, Yoshiro

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2012

Language:

english

File:

PDF, 117 KB

english, 2012

40

Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians

Hasunuma, Tomoko, Tohkin, Masahiro, Kaniwa, Nahoko, Jang, In-Jin, Yimin, Cui, Kaneko, Masaru, Saito, Yoshiro, Takeuchi, Masahiro, Watanabe, Hiroshi, Yamazoe, Yasushi, Uyama, Yoshiaki, Kawai, Shinichi

Journal:

British Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 976 KB

english, 2016

41

Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese

Maekawa, Keiko, Fukushima-Uesaka, Hiromi, Tohkin, Masahiro, Hasegawa, Ryuichi, Kajio, Hiroshi, Kuzuya, Nobuaki, Yasuda, Kazuki, Kawamoto, Manabu, Kamatani, Naoyuki, Suzuki, Kazuko, Yanagawa, Tatsuo, S

Journal:

Pharmacogenetics and Genomics

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

42

Chemical conversion of corticosteroids to 3.ALPHA.,5.ALPHA.-tetrahydro derivatives. Synthesis of allotetrahydro-11-deoxycortisol glucuronides.

HOSODA, HIROSHI, TAKASAKI, WATARU, MIURA, HIROYA, TOHKIN, MASAHIRO, MARUYAMA, YUKO, NAMBARA, TOSHIO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 861 KB

1985

43

Mutagenicity Testing of 1,3-Butadiene, 1,4-Pentadiene-3-ol , Isoprene, 2,4-Hexadiene, cis- and trans-Piperlylene

Madhusree, Bathini, Goto, Sumio, Ohkubo, Tadamichi, Tian, Hailin, Ando, Fukue, Fukuhara, Morio, Tohkin, Masahiro, Watanabe, Ikuo

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2002

Language:

english

File:

PDF, 160 KB

english, 2002

44

Analysis of DNA Adducts after Exposure to 1,4-Dichlorobenzene by 32P-Postlabeling Technique.

Tian, Hailin, Madhusree, Bathini, Fukuhara, Morio, Tohkin, Masahiro, Miyazawa, Hiroshi, Goto, Sumio

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2001

Language:

english

File:

PDF, 410 KB

english, 2001

45

Regulatory Science for the Proper Evaluation of Biomarkers (Overview)

Tohkin, Masahiro, Saito, Yoshiro

Journal:

YAKUGAKU ZASSHI

Year:

2015

Language:

english

File:

PDF, 703 KB

english, 2015

46

Regulatory Science on Biomarker Usage for Development and Proper Use of Drugs

Saito, Yoshiro, Tohkin, Masahiro

Journal:

YAKUGAKU ZASSHI

Year:

2015

File:

PDF, 162 KB

2015

47

Comparison of the action of epinephrine and a respiratory chain uncoupler, 2,4-dinitrophenol, on Ca2+-mobilization in isolated hepatocytes and perfused livers.

TOHKIN, Masahiro, YOSHIMATSU, Naomi, MATSUBARA, Takashi

Journal:

The Japanese Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 483 KB

english, 1988

48

Effects of adrenergic agonists and antagonists on glycogenolysis in isolated perfused rat liver.

TOHKIN, Masahiro, MATSUBARA, Takashi

Journal:

The Japanese Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 550 KB

english, 1987

49

Significant Association between Hand-Foot Syndrome and Efficacy of Capecitabine in Patients with Metastatic Breast Cancer

Azuma, Yuichiro, Hata, Kojiro, Sai, Kimie, Udagawa, Ryoko, Hirakawa, Akihiro, Tohkin, Masahiro, Ryushima, Yasuaki, Makino, Yoshinori, Yokote, Nobuaki, Morikawa, Norifumi, Fujiwara, Yasuhiro, Saito, Yo

Journal:

Biological & Pharmaceutical Bulletin

Year:

2012

Language:

english

File:

PDF, 427 KB

english, 2012

50

Sex difference in adrenergic receptor-mediated glycogenolysis in rat livers.

YAGAMI, Tatsurou, TOHKIN, Masahiro, MATSUBARA, Takashi

Journal:

The Japanese Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 591 KB

english, 1990